Research Paper Volume 1, Issue 1 pp 122—130
Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas
Figure 3. Development of genetically unstable T cell lymphoma in TRF2 overexpressing mice. (A) H&E staining of tumor tissue. Tissue samples from a secondary recipient mouse, which developed a blastic T cell lymphoma, involving liver, spleen and thymus. 10x and 40x magnifications are shown. The upper panels show sections of control tissue from a healthy C57BL/6J mouse. (B) Anaphase bridges in H&E stained liver and spleen sections from a secondary recipient mouse carrying a CD4/CD8+/+ T cell lymphoma. The arrows point to the chromatin bridges between the separating chromosomes. A dashed line outlines normal anaphases displayed in the images to the very left.