Research Paper Volume 1, Issue 11 pp 937—948

The circadian clock gene period extends healthspan in aging Drosophila melanogaster

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Figure 5. Expression of per mRNA declines with with age in heads of CSp flies. (A) Daily mRNA expression profiles of per in day 5, 35 and 50 male heads. White and black horizontal bars mark periods of light and darkness respectively. Values were normalized to rp49 and calibrated against ZT0 (taken as 1) for each age and represented as mean ± SEM of 3 bioreplicates. (B) The peak levels of per mRNA are significantly reduced (* = p<0.05) in 50 day old males compared to young control males. Values are mean ± SEM of 3 bioreplicates.