Priority Research Paper Volume 1, Issue 12 pp 979—987
Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1
Figure 3. Continuous administration of NAC increases lifespan of Bmal1-/- mice. Kaplan-Meyer survival curves were obtained for WT mice raised on regular (closed circles) or NAC-supplemented (open circles) water; and Bmal1-/- mice raised on regular (closed triangles) or NAC-supplemented (open triangles) water. NAC significantly increased lifespan of Bmal1-/- mice (P =0.022, log-rank Mantel-Haenszel test).