Research Paper Volume 2, Issue 12 pp 990—998

Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)


Figure 1. Effect of statn on chondrocyte aging in vitro.. Chondrocyte senescence was measured by the senescence-associated β-galactosidase (SA-β-Gal) activity assay. The chondrocytes were cultured with IL-1β (10 ng/ml) in the presence or absence of statin (1.0, 10.0 μM) for 5 days. (A-F) Representative images of SA-β-Gal staining, (A) control (medium only), (B) IL-1β-treated group, (C) statin (1.0 μM)-treated group, (D) IL-1β + sratin (1.0 μM)-treated group, (E) statin (10.0 μM)-treated group, (F) IL-1β + sratin (10.0 μM)-treated group. As shown in the representative images, whereas IL-1β stimulated the expression of SA-β-Gal in chondrocytes, treatment with statin markedly inhibited the expression of SA-β-Gal even in the presence of IL-1β stimulation. (G) Treatment with statin significantly inhibited the IL-1β-enhanced SA-β-Gal activity in the chondrocytes.