Research Perspective Volume 2, Issue 10 pp 742—747

Figure 1. Hypothetical model of FoxO regulation by the germline, IIS, and EAK-7. The nucleus is denoted by the dashed ellipse. A. In the presence of an intact germline and IIS, most FoxO is sequestered in the cytoplasm, and EAK-7 inhibits the activity of the small fraction of cellular FoxO that resides in the nucleus. B. In animals with reduced IIS and/or germline signaling, EAK-7 has a greater influence on FoxO activity, since relative concentrations of nuclear FoxO are increased.