Research Paper Volume 2, Issue 12 pp 981—989
CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits
Figure 3. CD36 deficiency enhances BM thickness in high fat high cholesterol fed ApoE−/− mice. (A) Plasma concentration of oxLDL in 4 months-old ApoE−/− mice under normal diet (ND) or high fat high cholesterol (HFHC) diet, and in double knockout ApoE−/−CD36−/− mice under HFHC diet was evaluated by ELISA. Transmission electron microscopy of Bruch's membrane (BM) thickening (arrows) in 4 months-old ApoE−/− (B) and ApoE−/−CD36−/− mice (C) both under HFHC diet. (D) Compiled BM thickness in 4-month-old ApoE−/− and ApoE−/−CD36−/− mice. Scale bars: 2μm. RPE refers to retinal pigmented epithelium. Values are mean ± SEM; n=4-6/group. *p<0.05, ** p<0.01, ***p<0.001, compared to values without asterisks.