Research Paper Volume 2, Issue 12 pp 981—989
CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits
Figure 4. CD36 stimulation reduces BM thickness in high cholesterol fed ApoE −/− mice. Transmission electron microscopy of Bruch's membrane (BM) thickening (arrows) in WT mice under ND (A), ApoE−/− mice under HFHC treated with NaCl (B) or EP80317 (C). HFHC diet increased BM thickness in ApoE−/− mice; this effect was prevented by CD36 stimulation using EP80317 (EP: 300 μg/kg, sc) (C,D). Scale bars: 1μm. RPE refers to retinal pigment epithelium, and Ch to choroid. Values are mean ± SEM; n=5/group. **p<0.05 compared to values without asterisks.