Research Paper Volume 2, Issue 12 pp 924—935
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
Figure 10. Serum stimulation converts Dox-locked quiescence into senescence in RPE cells. RPE cells were treated with 50 ng/ml doxorubicin (low-Dox) or left untreated in serum-free medium (no serum) for 3 days, then 10% serum was added. After 3 days of serum stimulation cells were stained for beta-Gal and microphotographed. Bar - 50 micron.