Research Paper Volume 3, Issue 8 pp 794—802

Figure 2. Circadian defects in the behavioral rhythm of CD38-KO mice. (A) Representative activity records (actograms) of Wild type (CD38^+/+) and CD38 knockout (CD38^-/-) mice are shown in double plotted format. Mice were entrained in 12 hr Light - 12 hr Dark cycles (LD) and then placed in constant darkness (DD) from the light off (ZT12), on day 1. (B) Bar graph representing the period length of WT and CD38-KO mice. Measurement of the free-running period was based on the onset of activity in DD. Data is represented as mean ± S.E. * *, p = 0.008, n= 6, 8. (C) Representative actograms of Wild type (CD38^+/+) and CD38 knockout (CD38^-/-) mice in LD cycle. (D) Bar graph representing % daily locomotor activity in a one-hour period at the indicated ZTs. Data represents mean ± S.E of 10 days of activity. *, p < 0.05; **, p<0.01 compared to the corresponding wild type, n= 6, 8. (E) Representative actograms from wheel running activity of Wild type (CD38^+/+) and CD38 knockout (CD38^-/-) mice in LD cycle. (F) Bar-graph representing total number of wheel rotations per day. Data is represented as mean ± S.E. **, p = 0.008, n= 6, 5.