Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease

Bing Song; Korbin Davis; X. Shawn Liu; Hyoung-gon Lee; Mark Smith; Xiaoqi Liu

doi:doi:10.18632/aging.100382

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Research Paper Volume 3, Issue 9 pp 846—851

Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease

Figure 1. An increased phosphorylation level of p150^Glued in AD neurons. Hippocampal tissues of AD patients or age-matched controls were subjected to immunohistochemistry staining with phospho-specific antibodies against pS179-p150^Glued. Plk1 phosphorylates p150^Glued-S179 specifically [27].