Review Volume 3, Issue 9 pp 829—835
Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair
Figure 1. The second wave of SIRT6 recruitment to DSBs is concomitant with global deacetylation of H3K9. Human fibroblasts were exposed to γ-irradiation. Immunoblotting revealed that H3K9-Ac levels are reduced 8 hours following irradiation, concurrent with a second wave of SIRT6 recruitment to DSBs.