Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

Lan Xiang; Yukiko Nakamura; Young-Mi Lim; Yasutoyo Yamasaki; Yumi Kurokawa-Nose; Wakako Maruyama; Toshihiko Osawa; Akira Matsuura; Noboru Motoyama; Leo Tsuda

doi:doi:10.18632/aging.100396

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Research Paper Volume 3, Issue 11 pp 1098—1109

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

Figure 3. THC inhibits Akt phosphorylation. Dose-dependence (A) and time-course (B) analyses indicate that THC inhibits phosphorylation of Akt^Ser473. LY294002 (LY) was used as a positive control, Akt and GAPDH antibodies as loading controls.