Research Perspective Volume 4, Issue 3 pp 159—165

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging


Figure 2. Strong oncogenic signaling, senescence and cancer.

(A) Strong mitogenic/oncogenic signal can simultaneously cause arrest and activate mTOR. Cells senesce. (B) Disabling of cell cycle control (loss of p16, Rb, p53) can convert senescence to cancer.