Research Paper Volume 4, Issue 6 pp 436—447

Figure 4. AS101 reverses HFD+STZ induced T2D.

(A) Course of experiment. (B) AS101 treatment prevents glucose increase in HFD+STZ induced T2D rat model. (*p<0.01 all groups vs. HFD+PBS group, n=6 in each group). (C) AS101 treatment maintains glucose tolerance. On day 17 (following the onset of diabetes) rats were fasted for 12 hours before i.p injection of 2mg/kg glucose. (*p<0.001 versus HFD+PBS+STZ, n=6 in each group). The histogram represents the incremental area under the glucose curve. (D) AS101 treatment maintains proper insulin levels in the serum of rats after 4 hours starvation (*p<0.001 all groups versus HFD+PBS+STZ, n=6 for each group). (E) AS101 preserves insulin production in the pancreas. Immunohistological staining for insulin (brown) and glucagon (red) of the rat pancreas. Pictures represent two out of the six animals in each group. Error bars represent the ±SEM.