Research Paper Volume 4, Issue 8 pp 567—577
A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction
Figure 1. A filtering strategy to identify effectors of lamin A dysfunction.
(A) Strategy utilized to identify FOXQ1 as a gene whose expression is altered in cells expressing progerin or elevated levels of prelamin A and reversed towards normal after treatment with FTIs or ZMPSTE24 overexpression. (B) Quantitative RT-PCR analysis of FOXQ1 expression in the indicated fibroblast lines confirms that FOXQ1 expression is upregulated in cells expressing elevated levels of prelamin A or progerin, and reverted towards normal after treatment with FTI or overexpression of ZMPSTE24.