Research Paper Volume 4, Issue 9 pp 606—619
Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus
Figure 2. Competence of thymic T-lymphopoiesis from aged- and young-LPCs in repopulation of grafted fetal thymic lobes in vivo in a time course manner.
(A) Thymocyte number in dGUO-treated (top panel) or intact (bottom panel) grafted fetal thymic lobes, at various weeks after transplanted under the kidney capsules of young (~2 months) and old (20 - 22 months) WT mice. The images shown are representative results of grafted thymic lobe size in the hosts? kidney capsules. Each data point (triangle or square) represents 2-3 host mice. (B) A representative result shows differentiation profiles (CD44 vs. CD25 at one-week time point, and CD4 vs. CD8 at all other longer time points) of thymocytes from grafted fetal thymic lobes under the young and old kidney capsules.