Research Paper Volume 4, Issue 9 pp 620—635
RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice
Figure 1. Aging causes loss of mtDNA copy numbers and mtDNA transcription.
(top row) qPCR analyses of mtDNA gene levels in gDNA from young (5 month, n=6) and old (21 month, n=9) brains (left), hearts (middle) and skeletal muscle (right), expressed as % mean young mouse levels. For brains and hearts, all differences between young and old animals are significant at p<0.0001; for muscle, differences between young and old CO3 levels were significant at p=0.036. No other genes had significant differences between young and old animals (all by unpaired t-test). (bottom row) qPCR analyses of mtRNA gene levels as cDNA?s in young (5 month, n=6) and old (21 month, n=9) brains (left), hearts (middle) and skeletal muscle (right), expressed as % mean young mouse levels. For brains, all differences between young and old animals are significant at p<0.0001; for heart, all differences between young and old are significant at p=0.001 or less; for muscle, differences between young and old are not significant (all by unpaired t-test).