Research Paper Volume 4, Issue 9 pp 620—635
RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice
Figure 6. RhTFAM treatment improves brain mitochondrial functions and lowers oxidative stress damage to brain proteins and lipids.
Effects of rhTFAM on various mitochondrial parameters in aged mice. Brain mitochondrial pellets from rhTFAM (low and high dose) and vehicle treated 21-22 month old mice were assayed for levels of various OXPHOS subunits (A), Complex I and IV activities (B and C, respectively), total ATP (D) and TBARS (E) as a measure of oxidative stress. RhTFAM treatment significantly increased all mitochondrial measures except for oxidative stress, where the low dose produced a significant decline in levels of TBARS. Unless otherwise noted, * p<.05 by paired t-test.