Research Paper Volume 4, Issue 9 pp 620—635
RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice
Figure 9. RhTFAM treatment increases brain levels of BDNF and synapsin.
Brain levels of proteins assayed by Western blot after treatment of 21 month old mice with rhTFAM once/week for four weeks. Shown are sizes of single rhTFAM doses. Protein levels are normalized to beta-actin and are expressed as % mean CTL. Statistical differences: BDNF (p=0.028 (control v 0.5mg/kg), p=0.029 (control v. 1.5mg/kg), p<0.001 (0.5mg/kg v 1.5mg/kg); PGC-1a (NS); PSD-95 (NS); synapsin (p<0.001 (control v. 1.5mg/kg), p=0.005 (0.5mg/kg v. 1.5mg/kg))