Research Paper Volume 4, Issue 10 pp 715—722

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis

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Figure 2.

Rapatar increases lifespan in p53−/− mice. Mice received Rapatar at 0.5 mg/kg via gavage according to the schedule described in Materials and Methods. Rapatar increased lifespan from 23 to 31 weeks (p<0.001, Mantel-Cox log-rank test).