Research Paper Volume 4, Issue 11 pp 803—822

Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells

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Figure 5. Electrical stimulation inducing nuclear abnormality in cardiomyocytes derived from LMNAR225X/WT &LMNAFrameshift/WT iPSCs.

(A) Representative immunofluorescence staining of cardiomyocytes derived from LMNAWT/WT iPSCs, LMNAR225X/WT iPSCs, LMNAFrameshift/WT iPSCs, LMNAWT/WT iPSCs treated with mock shRNA, and LMNAWT/WT iPSCs treated with shLMNA at baseline and after electrical stimulation. (B) The percentage of cardiomyocytes showed nuclear blebs.