Research Paper Volume 4, Issue 11 pp 755—767

Figure 3.

The effect of MIA-690 on the behavioral parameters of the 5XFAD transgenic mice in the spatial acquisition of the MWM experiments, during the 1^st and 6^th month. Mice were treated with daily subcutaneous injections of GHRH antagonist MIA-690 at doses of 2, 5, and 10 μg for 6 months. The pooled standard errors (PSE)s of the groups were the following (A) control: 28.32, MIA-690 (2 μg): 44.1, MIA-690 (5 μg): 25.5, MIA-690 (10 μg): 37.6; (B) control: 30.8, MIA-690 (2 μg): 47.4, MIA-690 (5 μg): 25.0, MIA-690 (10 μg): 43.2; (C) control: 20.1, MIA-690 (2 μg): 15.9, MIA-690 (5 μg): 17.6, MIA-690 (10 μg): 28.6; (D) control: 22.0, MIA-690 (2 μg): 16.6, MIA-690 (5 μg): 19.8, MIA-690 (10 μg): 23.5. * = p < 0.05 vs. control according to repeated measure general linear model analysis.