Research Paper Volume 4, Issue 11 pp 790—802
The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients
Figure 2. DNA binding is not significantly affected by mutations.
(A) Amalgamated gel from representative experiments showing DNA binding of WT and mutants at 0, 12.5, 25, 50 and 100 nM protein. (B) Binding data compiled from triplicate experiments. Mutants universally appear to have slightly reduced binding compared to wild-type, but the difference is not significant. Error bars represent standard error of mean from three experiments.