Research Paper Volume 4, Issue 11 pp 823—842
Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells
Figure 4. Relative abundance of histone H2A family in proliferating and bleomycin-treated cells.
The AGLQFPVGR and HLQLAIR peptide sequences are common to all H2A histone family types (3A). The relative nuclear abundance of both the peptides, as measured by SRM, is shown for proliferating, acute DNA damage, and drug-evoked senescence HCA2 cells. Eight biological replicates were used for each condition. The p-values were calculated using Student's t-test, two-tailed, unequal variance, between the conditions.