Research Paper Volume 5, Issue 1 pp 3—17
Structural and functional association of androgen receptor with telomeres in prostate cancer cells
Figure 1. AR antagonists cause a TIF response.
(A), LNCaP cells treated with or without Casodex for 24 hrs were analyzed for the percentage of cells with >5 53BP1 foci/cell; data are expressed relative to untreated control cells. (B), PSA mRNA levels in cells from (A) were measured by RT-PCR. RPL-19 is a loading control. (C), LNCaP cells were treated with or without Casodex (50 μM, 100 μM) or MDV 3100 (3 μM, 10 μM) for 24 hr, then evaluated for the percentage of cells with >5 53BP1 foci/cell.