Research Paper Volume 5, Issue 2 pp 130—141
Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction
Figure 3. Known miRNAs for which calorie restriction antagonizes an age-associated increase in circulating levels.
Shown are the serum levels of miRNAs (Y-axis) derived from the miRNA genes indicated in the X-axis (labeled with miRBase v.19 terminology). Serum levels of miRNAs are reported as the average counts per million (cpm) reads in the sequenced libraries from the 3 experimental groups: young control (blue bars), old control (red bars), and old CR (green bars). The fold change and p-values of the age and CR effects on these and other circulating miRNAs are reported in Table