Research Perspective Volume 5, Issue 3 pp 144—150
The sirtuins, oxidative stress and aging: an emerging link
Figure 2. Regulation of ROS by sirtuins.
Diagram showing how ROS, aging, and caloric restriction interact to influence the activity of the cytoplasmic/nuclear sirtuin, SIRT1, and the mitochondrial sirtuin, SIRT3. Upon activation, SIRT1 and SIRT3 deacetylate several proteins that promote resistance to oxidative stress. Arrows indicate positive regulation while hash-marks indicate negative regulation. Solid lines reflect robust experiment evidence for an interaction while dashed lines indicate putative interactions.