Research Perspective Volume 5, Issue 3 pp 144—150

The sirtuins, oxidative stress and aging: an emerging link

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Figure 2. Regulation of ROS by sirtuins.

Diagram showing how ROS, aging, and caloric restriction interact to influence the activity of the cytoplasmic/nuclear sirtuin, SIRT1, and the mitochondrial sirtuin, SIRT3. Upon activation, SIRT1 and SIRT3 deacetylate several proteins that promote resistance to oxidative stress. Arrows indicate positive regulation while hash-marks indicate negative regulation. Solid lines reflect robust experiment evidence for an interaction while dashed lines indicate putative interactions.