www.mitodb.com, containing the clinical features of primary mitochondrial diseases. Based on this we developed a number of qualitative and quantitative measures, enabling us to determine whether a disorder can be characterized as mitochondrial. These included a clustering algorithm, a disease network, a mitochondrial barcode and two scoring algorithms. Using these tools we detected mitochondrial involvement in a number of diseases not previously recorded as mitochondrial. As a proof of principle Cockayne syndrome, ataxia with oculomotor apraxia 1 (AOA1), spinocerebellar ataxia with axonal neuropathy 1 (SCAN1) and ataxia-telangiectasia have recently been shown to have mitochondrial dysfunction and those diseases showed strong association with mitochondrial disorders. We next evaluated mitochondrial involvement in aging and detected two distinct categories of accelerated aging disorders, one of them being associated with mitochondrial dysfunction. Normal aging seemed to associate stronger with the mitochondrial diseases than the non-mitochondrial partially supporting a mitochondrial theory of aging.

" name="description"> A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging - Figure F1 | Aging
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Research Paper Volume 5, Issue 3 pp 192—208

A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging

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Figure 1. Mitochondrial diseases have a defined clinical spectrum.

(A) The top-20 clinical parameters seen in all mitochondrial diseases. (B) The top-20 clinical parameters seen in mitochondrial diseases with a mean age of onset before 20. (C) The top-20 clinical parameters seen in mitochondrial diseases with a mean age of onset after 20.