Research Paper Volume 5, Issue 4 pp 234—269
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis
Figure 1. Under CR conditions, the atg32Δ-dependent mutational block of macromitophagy substantially shor-tens yeast CLS and abolishes the longevity-extending effect of LCA.
WT and atg32Δ strains were cultured in the nutrient-rich YP medium initially containing 0.2% glucose in the presence or absence of 50 μM LCA. Effect of theatg32Δ mutation and LCA on survival (A) and on the mean (B) and maximum (C) lifespans of chronologically aging yeast grown under CR conditions on 0.2% glucose. Data are presented as means ± SEM (n = 6-8; *p < 0.01). Abbreviations: Diauxic (D), logarithmic (L), post-diauxic (PD) or stationary (ST) growth phase.