Research Paper Volume 5, Issue 4 pp 234—269

Figure 10. A working model for a mechanism that in atg32Δ cells underlies the spatiotemporal dynamics of age-related changes in lipid synthesis in the ER and mitochondria as well as in lipid transport via mitochondria-ER (MAM) and PM-ER (PAM) junctions.

During logarithmic (A), diauxic (B) and post-diauxic (C) phases of growth under CR conditions, a remodelling of lipid synthesis and transport in atg32Δ cells alters the membrane lipidomes of mitochondria, the ER and the PM. From the data of lipidomic analysis, we inferred an outline of lipid synthesis and transport processes that were activated (red arrows) or inhibited (blue arrows) by the atg32Δ-dependent mutational block of macromitophagy; the thickness of these arrows correlates with the rates of the processes taking place in atg32Δ cells. Arrows next to the names of lipid species denote those of them whose concentrations are elevated (red arrows) or reduced (blue arrows) in atg32Δ cells. See text for details.