Research Paper Volume 5, Issue 4 pp 234—269

Figure 2. Under CR conditions, the atg36Δ-dependent mutational block of macropexophagy does not alter yeast CLS and does not compromise the longevity-extending efficacy of LCA.

WT and atg36Δ strains were cultured in the nutrient-rich YP medium initially containing 0.2% glucose in the presence or absence of 50 μM LCA. Effect of theatg36Δ mutation and LCA on survival (A) and on the mean (B) and maximum (C) lifespans of chronologically aging yeast grown under CR conditions on 0.2% glucose. Data are presented as means ± SEM (n = 5-6; *p < 0.01; ns, not significant). Abbreviations: Diauxic (D), logarithmic (L), post-diauxic (PD) or stationary (ST) growth phase.