Research Paper Volume 5, Issue 4 pp 270—275
Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner
Figure 4. Life span extension through fibrates is NHR-49/PPARalpha-dependent.
A Life span analyses with several hundred nhr-49 knockout nematodes (variation ok2165, strain RB1716) at 10 micromolar bezafibrate, clofibrate, and fenofibrate versus control (0.1% DMSO). B Life span analyses with several hundred nhr-49 knockout nematodes (variation gk405, strain VC870) at 10 micromolar bezafribrate, clofibrate, and fenofibrate versus control (0.1% DMSO).