Research Paper Volume 5, Issue 6 pp 394—411
Age-related micro-RNA abundance in individual C. elegans
Figure 4. mir-71 acts at least partly in parallel to the IIS pathway.
(A) The integrated transgene maIs352[Pmir-71::mir-71::GFP] partially rescues the lifespan of mir-71 null mutants. (B) The longevity phenotype of daf-2(e1368) is significantly suppressed by the presence of the mir-71(n4115) deletion. (C) daf-16; mir-71 double null mutants show significant enhancement relative to the single mutants. (D) Over-expression of mir-71 extends the lifespan of daf-16 null mutants.