Research Paper Volume 5, Issue 6 pp 412—426

Figure 2. The transcriptome of the OPMD mouse model is highly associated with aging.

(A) Volcano plot shows the distribution of significantly deregulated genes (P = 0.05; indicated with a dashed line) in 6 week-old A17.1 mice against fold-change. Smaller P-value and higher fold-change suggests a higher impact in OPMD. For every gene a literature-associated weight with the ‘Aging' concept is assigned, and a normalized association-weight is presented with a circle on a linear scale between 0.05 and 1, where 1 equals the highest association. (B) Hierarchical clustering arrangements of 104 datasets in a literature-aided meta-analysis. Shades of blue indicate degree of similarities: from weak (white) to strong (dark blue). Three skeletal muscle aging-related datasets cluster together with the OPMD dataset of 6 week-old mice (highlighted in red). The clusters associated with muscular dystrophies and other myopathies are highlighted in green and blue, respectively.