Research Paper Volume 5, Issue 6 pp 412—426
A decline in PABPN1 induces progressive muscle weakness in Oculopharyngeal muscle dystrophy and in muscle aging
Figure 4. Deregulation of the Spliceosome in both OPMD and elderly.
(A) Bar-chart shows fold-change of spliceosome genes in OPMD and elderly from the transcriptome studies. P-values are indicated: * P<0.05, ** P<0.005, *** P<0.0005. In bold are gene-hubs in the OPMD-affected spliceosome network (B). A schematic gene network presentation of OPMD-regulated genes that are grouped in the spliceosome GO category. PABPN1 is highlighted