Research Perspective Volume 5, Issue 7 pp 490—494
M(o)TOR of aging: MTOR as a universal molecular hypothalamus
Figure 2. Mutual overstimulation of MTOR in beta-cells and insulin-dependent tissues.
Mutual and reciprocal over-stimulation leads to cellular hyperfunctions and secondary signal-resistance. By negative feedback, overactivated MTOR blocks insulin signaling. See text for explanation. Yellow cell: hepotocyte, adipocyte or muscle cell. Blue cell: beta-cell of the pancreas.