Research Paper Volume 5, Issue 8 pp 607—622

Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production

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Figure 3.

Assessing oxidative DNA damage and cell death in cerebral cortex twelve months after radiation. (A) Immunohistochemical staining of cerebral cortex for 8-oxo-dG after exposure to γ and 56Fe radiation. (B) Quantification of 8-oxo-dG staining in cerebral cortex presented as mean ± SEM. (C) TUNEL staining of cerebral cortex after exposure to γ and 56Fe radiation. (D) Quantification of TUNEL staining of cerebral cortex after exposure to γ and 56Fe radiation presented as mean ± SEM. (E) Measurement of cerebral cortex thickness in H&E stained histological sections presented as mean ± SEM.