Research Paper Volume 5, Issue 9 pp 643—652

CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging


Figure 2. Increased numbers of CD4+ T cells in aged mice.

Bone marrow cells from 3 and 12 months old WT, CD137−/− and CD137L−/− mice were stained for CD3, CD137, CD4 and CD8. (A) Gating strategy of CD137+ T cells. (B,C) Numbers of (B) CD137+, CD4+ and (C) CD137+, CD8+ T cells. (D,E) Numbers of (D) CD137, CD4+ and of CD137, CD8+ T cells. Each group consisted of at least 5 mice. Data are representative of two independent experiments. *p<0.05.