Research Paper Volume 5, Issue 9 pp 643—652

CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging

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Figure 6. Schematic representation of CD137 – CD137L interactions in age-related myelopoiesis.

Depicted is the situation for 12 months old WT, CD137−/− and CD137L−/− mice. The absence of CD137 on activated CD4+ T cells or of CD137L on hematopoietic progenitor cells leads to a reduced number of myeloid cells in CD137−/− and CD137L−/− mice, respectively.