Research Paper Volume 5, Issue 10 pp 725—740

Age-related changes in microRNA levels in serum

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Figure 1. Identification of miRNAs in serum from young and old individuals.

(A) Frequency of miRNA reads per individual using small RNA NGS from 11 young (~30 yr) and 11 old (~64 yr) individuals for miR-181a-1, miR-3607, miR-1248, miR-151a and miR-151b. Horizontal lines represent average number of reads. miR-181a, miR-1248 and miR-3607 were significantly downregulated in serum from old individuals using Poisson regression (miR-181a-1 P=0.03, miR-3607 P=0.01, miR-1248 P=4.9×10−9). (B) miRNAs identified that had only one read per individual.