Research Paper Volume 5, Issue 10 pp 759—769

A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

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Figure 2. FUdR upregulates transcriptional expression of the heat shock regulated chaperone hsp16.2 after heat stress.

A, B, Fluorescent photomicrographs of animals expressing the transcriptional reporter, phsp16.2::GFP, after heat stress in the absence or presence of FUdR (100 μg/ml). Worms were heat stressed for 1 hour at 35°C and GFP expression was analyzed approximately 5 hours later. C, Quantification of GFP expression from A, B. FUdR-treatment significantly increases GFP levels compared to untreated control animals. (**=p<0.0001, Student's t-test)