Research Paper Volume 5, Issue 12 pp 884—901
eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies
Figure 8. ROS contributes to doxorubicin-mediated induction of senescence in tumor cells.
HT1080 WT and KI cells (A,B) as well as A549 WT and KI cells (C,D) were treated with 30 nM doxorubicin (Dox) in the absence (Con) or presence of 200 μM Trolox (T) for 36 hours. Cells were stained for SA β-Gal; histograms represent the average percentage values of SA β-Gal positive cells from three independent experiments. Senescent cells are shown in blue color.