Research Paper Volume 6, Issue 1 pp 70—81
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks
Figure 4. Accumulation of WRN wild type and phosphorylation mutants at laser-induced DSBs.
HeLa cells overexpressing either EGFP-WRN wild type (WT) or mutant (S440A, S467A or S440A/S467A) were laser-irradiated at the sites indicated by arrows. Time-dependent accumulation of EGFP-WRN WT and mutants at the DSBs sites were shown.