Research Paper Volume 6, Issue 1 pp 26—34
Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma
Figure 4. Hepatocyte transplantation reverses the RS-induced senescent phenotype.
Expression of cyclin D1, p21 and IL-6 in control rat liver and rat liver exposed to either DENA+RS or DENA+RS followed by normal hepatocyte transplantations. All gene products were highly expressed in DENA+RS-treated livers, while their levels were near control values in animals receiving hepatocyte transplantation (panels A and B). ***Significantly different from non-transplanted animals: P<0.005.