Research Paper Volume 6, Issue 3 pp 207—214
Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose
Figure 1.
Four major pathways of glucose metabolism underlying glucotoxicity. Azaserine inhibits GFAT. GFAT; glutamine: fructose-6-phosphate amidotransferase, DHAP: dihydroxyacetone phosphate, DAG: diacylglycerol, AGE: advanced glycation product.