Research Paper Volume 6, Issue 4 pp 264—280
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell
Figure 3.
Dys-functional activity of hMSCs which accumulate prelamin A in vivo. (A) Perfusion rate in mice after transplanting hMSCs. ** p<0.01, * p<0.05. (B) Laser-Doppler quantification of hind limb blood flow over time after hMSCs transplantation (Post-isch = blood flow measured immediately after ischemia). ** p<0.01 and * p<0.05 when compared versus vehicle, & p<0.05 when compared versus control hMSCs. (C) Representative photographs of animal hind limbs (left) and PET images (right) 14 days after ischemia and hMSCs transplantation.
Bars are average +/- standard deviation (panel A) or standard error of the mean (panel B).
(pre): prelamin A-accumulating hMSCs, (ctrl): control-hMSCs.