Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Gianluca Sgarbi; Paola Matarrese; Marcello Pinti; Catia Lanzarini; Barbara Ascione; Lara Gibellini; Emi Dika; Annalisa Patrizi; Chiara Tommasino; Miriam Capri; Andrea Cossarizza; Alessandra Baracca; Giorgio Lenaz; Giancarlo Solaini; Claudio Franceschi; Walter Malorni; Stefano Salvioli

doi:doi:http://dx.doi.org/10.18632/aging.100654

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Research Paper Volume 6, Issue 4 pp 296—310

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Figure 1. Mitochondrial mass increases in DFs from LLI.

(A) Citrate synthase activity expressed as nmol/min/mg of total cellular protein; (B) protein content expressed as μg protein/10⁶ cells ratio; (C) citrate synthase activity expressed as nmol/min/10⁶ cells; *p<0.05 LLI vs Old and **p<0.01 LLI vs Young. Data are presented as the mean value ± SD. Two independent experiments were performed on DFs of each donor.