Research Paper Volume 6, Issue 4 pp 335—350

Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies

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Figure 6.

Indy mutations preserve ISC homeostasis. INDY transports citrate from hemolymph into the cells and vice versa. Cytoplasmic citrate can be transported to mitochondria and used as a substrate for the TCA cycle. Reduced INDY-mediated transport decreases citrate levels and decreases the ATP/ADP ratio. Such changes activate AMPK, promoting fat oxidation and dPGC-1 synthesis. The increase in dPGC-1 activity increases mitochondrial biogenesis and transcription of ROS-detoxification genes. Decreased ROS production preserves ISC homeostasis, which contributes to Indy mediated longevity extension.