Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Aleksandra Borodkina; Alla Shatrova; Polina Abushik; Nikolay Nikolsky; Elena Burova

doi:doi:http://dx.doi.org/10.18632/aging.100673

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Research Paper Volume 6, Issue 6 pp 481—495

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Figure 7.

(A) Immunoblot analysis of p38 phosphorylation during 1 h H₂O₂ treatment. (B) SB had no effect on long-term p38 phosphorylation as detected by Western blot. (C) Selective inhibition of p38 activity abolished phosphorylation of MAPKAPK-2 during the whole observation period. Representative results of three independent experiments are shown. GAPDH was used as loading control.