Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Aleksandra Borodkina; Alla Shatrova; Polina Abushik; Nikolay Nikolsky; Elena Burova

doi:doi:http://dx.doi.org/10.18632/aging.100673

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Research Paper Volume 6, Issue 6 pp 481—495

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Figure 9. SB diminished ROS production and mitochondrial function in senescent hMESCs.

(A) DCF, (B) DHR123, (C) Rho123, and (D) NAO fluorescence in control (Ctr), H₂O₂-treated and (SB+H₂O₂)-treated hMESCs at indicated time points as measured by flow cytometry (M ± SD, N = 3, *p<0.05, ***p<0.001, versus control, §p<0.05, §§§<0.001, versus H₂O₂-treated cells).