Research Paper Volume 6, Issue 6 pp 481—495

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

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Figure 9. SB diminished ROS production and mitochondrial function in senescent hMESCs.

(A) DCF, (B) DHR123, (C) Rho123, and (D) NAO fluorescence in control (Ctr), H2O2-treated and (SB+H2O2)-treated hMESCs at indicated time points as measured by flow cytometry (M ± SD, N = 3, *p<0.05, ***p<0.001, versus control, §p<0.05, §§§<0.001, versus H2O2-treated cells).